Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript.
نویسندگان
چکیده
Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT(-) virus but not with LAT(+) viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.
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عنوان ژورنال:
- Science
دوره 287 5457 شماره
صفحات -
تاریخ انتشار 2000